The Lostwood National Wildlife Refuge is located 20 minutes north of Stanley on Highway 8. It lies within the prairie pothole region that produces more ducks than any other region in the lower 48 states. Lostwood National Wildlife Refuge (NWR) lies in the heart of the Missouri Coteau region, an ancient glacial moraine area. Topography ranges from rolling to steep hills and is covered by mixed-grass prairie. The area is dotted with wetlands that are often called "potholes." At 27,589 acres, the Refuge contains a 5,577-acre Wilderness Area established in 1975.